Table 7.
Association analysis between combination of rs28649799 and rs4693608 SNPs and the number of CD34+ cells following administration of G-CSF to healthy donors after the first apheresis.
| Parameters | Total | CMV-Seropositive | CMV-Seronegative | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Median (Range) | Comparisons to Carriers |
p-Value | Genotype | Median (Range) | Comparisons to Carriers |
p-Value | Genotype | Median (Range) |
Comparisons to Carriers |
p-Value | |
| CD34+ × 106 total yield |
AA-AA (68) |
786.6 (678.3–874.4) |
AA-AA to AA-GG |
0.074 | AA-AA (45) |
812.5 (718.2–930.0) |
AA-AA to AA-GG |
0.032 | AA-AA (20) |
733.5 (517.6–1129.2) |
AA-AA to AA-GG |
0.39 |
| AA-AG (68) |
723.5 (634.0–789.2) |
AA-AA to others |
0.17 | AA-AG (52) |
701.6 (549.4–774.9) |
AA-AA to others |
0.021 | AA-AG (12) |
836 (545.9–1022.8) |
AA-AA to others |
0.97 | |
| AA-GG (34) |
643.9 (492.3–772.9) |
AA-GG to others |
0.086 | AA-GG (24) |
561.9 (466.1–729.4) |
AA-GG to others |
0.091 | AA-GG (7) |
772.9 (329.7–1196.6) |
AA-GG to others |
0.37 | |
| %CD34+ | AA-AA (67) |
0.88 (0.77–0.99) |
AA-AA to AA-GG |
0.029 | AA-AA (44) |
0.89 (0.76–1.02) |
AA-AA to AA-GG |
0.021 | AA-AA (20) |
0.86 (0.65–1.16) |
AA-AA to AA-GG |
0.41 |
| AA-AG (68) |
0.75 (0.69–0.81) |
AA-AA to others |
0.013 | AA-AG (52) |
0.73 (0.6–0.77) |
AA-AA to others |
0.003 | AA-AG (12) |
1.11 (0.62–1.38) |
AA-AA to others |
0.71 | |
| AA-GG (34) |
0.74 (0.58–0.84) |
AA-GG to others |
0.15 | AA-GG (24) |
0.69 (0.45–0.83) |
AA-GG to others |
0.18 | AA-GG (7) |
0.74 (0.27–1.29) |
AA-GG to others |
0.23 | |
Significant deviations (p < 0.05) are marked in bold.