AD	Alzheimer disease
LOAD	Late-Onset Alzheimer Disease
EOAD	Early-Onset Alzheimer Disease
MCI	Mild cognitive impairment
CNS	Central nervous system
CSF	Cerebrospinal fluid
PFC	prefrontal cortex
EWAS	Epigenome-wide association study
GWAS	Genome-wide association study
NGS	Next-generation sequencing
WES	Whole-exome sequencing
WGS	Whole-genome sequencing
MGAS	Multivariate gene association analysis
PPI	Protein–protein interaction
p-Tau	Phosphorylated protein tau
CGIs	CpG islands
Aβ	Amyloid-β peptide
Aβ42	Amyloid-β 42
NFTs	Neurofibrillary tangles
APP	Amyloid-β precursor protein
APP-Aβ	β-amyloid domain containing APP
APP-CTF	APP C-terminal fragment
BACE1	β-site amyloid precursor protein cleaving enzyme 1
BACE2	β-site amyloid precursor protein cleaving enzyme 2
ApoE	Apolipoprotein E
ApoE2	Apolipoprotein ε2
ApoE3	Apolipoprotein ε3
ApoE4	Apolipoprotein ε4
APOC1	Apolipoprotein C1
BIN1	Bridging Integrator 1
CLU	Clusterin
PICALM	Phosphatidylinositol-binding clathrin assembly protein
TOMM40	Translocase of outer mitochondrial membrane 40
CR1	Complement receptor type 1
ANK1	Ankyrin 1
CDH23	Cadherin-related 23
CaMKIV	Calcium/calmodulin-dependent protein kinase type IV
DIP2A	Disco-interacting protein 2 homolog A
RHBDF2	Inactive rhomboid protein 2
RPL13	60S ribosomal protein L13
SERPINA3	Serpin family A member 3
SERPINF	Serpin family F member
AICD	APP intracellular domain
CBP	CREB-binding protein
MAPT	Microtubule-associated protein Tau
IGF-I	Insulin-like growth factor 1
GLUT4	Glucose transporter Type 4
PSEN1	Presenilin 1
PSEN2	Presenilin 2
SORL1	Sortilin-related receptor 1
ADAM10	A disintegrin and metalloprotease 10
PTM-Hs	Post-translational modification of histones
DMRs	Differentially methylated regions
SAM	Methyl donor S-adenosylmethionine
SIRT1	Sirtuin 1
RNase P	Ribonuclease P
TER	Telomerase RNA
TET	Ten–eleven translocation
SUMO	Small ubiquitin-like modifier
DGCR8	Microprocessor complex subunit DGCR8
DNMT	DNA methyltransferase
HAT	Histone acetyltransferase
HDAC	Histone deacetylase
HDACi	HDAC inhibitors
ICBs	Immune checkpoint blockers
siRC	silencing RNA-induced complex
RBL2	Retinoblastoma-like 2 protein
HDL	High-density lipoproteins
VLDL	Very low-density lipoprotein
NF-κB	Nuclear transcription factor kappa B
ncRNA	Noncoding RNA
miRNA	MicroRNA
piRNA	Piwi-interacting RNA
rRNA	Ribosomal RNA
snRNA	Small nuclear RNA
tRNA	Transfer RNA
snoRNA	Small nucleolar RNA