Schematic drawing of the atrial septal anatomy seen from the right atrium (redrawn from Calvert, P., Rana, B., Kydd, A. et al. Patent foramen ovale: anatomy, outcomes, and closure. Nat Rev Cardiol 8, 148–160 (2011). https://doi.org/10.1038/nrcardio.2010.224 accessed date 28 October 2021.). The fossa ovalis (FO) is composed by the septum primum and the septum secundum and the usual location of the PFO is on the anterosuperior border of the FO. AO, aorta; FO, fossa ovalis; IVC, inferior vena cava; PFO, patent foramen ovale; PV, pulmonary valve; RV, right ventricle; SVC, superior vena cava; TV, tricuspid valve.