Table 6.
Associations between WQS regression index and serum lipids (mg/dL), blood pressure (mmHg) and BMI. WQS regression model weights of each PFAS component, for each outcome.
| ADOLESCENTS | |||||||
| Outcome | TC | HDL-C | LDL-C | TG | BMI | SBP | DBP |
|
β*
95% CI |
2.35 [1.47, 3.23] |
0.68 [0.34, 1.01] |
1.79 [0.99, 2.59] |
0.01 [0, 0.02] |
−0.08 [−0.12, −0.04] |
−0.04 [−0.46, 0.37] |
−0.05 [−0.33, 0.24] |
| PFAS | Weights for each outcome | ||||||
| PFOA | 0.03 | 0.00 | 0.08 | 0.99 | 0.22 | 0.57 | 0.06 |
| PFOS | 0.83 | 0.99 | 0.54 | 0.00 | 0.78 | 0.00 | 0.00 |
| PFHxS | 0.14 | 0.01 | 0.38 | 0.01 | 0.00 | 0.43 | 0.94 |
| CHILDREN | |||||||
| Outcome | TC | HDL-C | LDL-C | TG | BMI | SBP | DBP |
|
β*
95% CI |
2.43 [1.24, 3.62] |
1.14 [0.58, 1.70] |
1.49 [0.41, 2.58] |
−0.01 [−0.03, 0.01] |
−0.1 [−0.17, −0.03] |
−0.38 [−0.87, 0.1] |
0.19 [−0.22, 0.61] |
| PFAS | Weigths for each outcome | ||||||
| PFOA | 0.03 | 0.09 | 0.03 | 0.52 | 0.09 | 0.01 | 0.61 |
| PFOS | 0.96 | 0.82 | 0.94 | 0.40 | 0.51 | 0.92 | 0.32 |
| PFHxS | 0.01 | 0.09 | 0.03 | 0.08 | 0.40 | 0.06 | 0.07 |
*β represents the increase in cholesterol level and blood pressure associated with a quartile increase in the WQS index. In bold weights that exceed the case of uniform weights (≥(number of chemicals) − 1 = 0.33).