Figure 1.

Structural features of RecQ helicases. (A) The RecQ proteins have domains that are conserved from bacteria through humans. The core helicase domain (dark blue box) is found throughout the protein family. However, unlike the other members of the RECQ family, RECQL4 is missing both the RQC (dark green box) and HRDC (red box) domains. With the exception of yeast, the RECQL4 family (including H. sapiens, X. laevis, D. melanogaster) have a conserved Sld-like domain, which is crucial replication initiation (light green box). In yeast, Sld2 is encoded as a separate protein. The nuclear localization sequence is indicated by a purple box and the exonuclease domain of WRN with a light blue box. (B) Interaction domains and post-translational modified regions of RECQL4. The mitochondrial localization sequence is located in the first 100 amino acid of RECQL4. Protein interactions with RECQL4 with BLM, MCM10, KU70, MRE11, OGG1, p300, p53, and PARP-1 are indicated by brackets. Phosphorylation sites (S89, T93, T139, S251) are indicated by a yellow circled P, acetylation sites (K376, K380, K382, K385, K386) by pink circled Ac, and ubiquitylation sites (K876, K1048, K1101) by purple circled Ub. Created by using Illustrator for Biological Sequences (IBS) [7].