FIG. 1.

Primary structure of PRC. (A) Predicted amino acid sequence of PRC. Regions of significant sequence similarity with PGC-1 are in boldface letters. The coactivator signature LXXLL is boxed; the proline-rich region is within brackets. The underlined sequence represents the RS domain, and the double underlined sequence represents the RNA recognition motif. (B) Alignment of similar domains in PRC and PGC-1. Regions of similarity between the two proteins are as follows: activation domain (stippled box), proline-rich region (cross-hatched box), RS domain (solid box), and RNA recognition motif (vertically hatched box). Amino acid coordinates are indicated above and below.