Table 1.
Players of the SUMO pathway in humans, Saccharomyces cerevisiae and Schizosaccharomyces pombe.
| SUMO Pathway Component | Humans | S. cerevisiae | S. pombe | |
|---|---|---|---|---|
| Small ubiquitin-like modifier (SUMO) | SUMO-1, SUMO-2, SUMO-3, SUMO-4, SUMO-5 |
Smt3 | Pmt3 | |
| Activating enzyme (E1) | SAE1 SAE2 |
Aos1 Uba2 |
Rad31 Fub2 |
|
| Conjugating enzyme (E2) | Ubc9 | Ubc9 | Hus5 | |
| SUMO ligase (E3) | SP-RING type | PIAS1, PIAS2, PIAS3, PIAS4 Mms21 |
Siz1, Siz2 Mms21 Zip3 |
Pli1Nse2 |
| other | RanBP2 * [69] HDAC4 [70], KPA1 [71], Pc2 [72], Topors [73] |
|||
| SUMO-targeted ubiquitin ligase (STUbL) | RNF4 RNF11 |
Slx5-Slx8 Uls1 |
Rfp1/Rfp2-Slx8 Rrp2 (predicted) |
|
| Sentrin/SUMO-specific protease (SENP) | SENP1 °,*, SENP2 °,*, SENP3, SENP5 ° SENP6, SENP7 |
Ulp1 °,* Ulp2 |
Ulp1 °,* Ulp2 |
|
* Localized at the nuclear pore complex. ° Involved in SUMO maturation.