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. 2021 Nov 24;12(12):1870. doi: 10.3390/genes12121870

Figure 6.

Figure 6

The circRNA–miRNA–mRNA regulatory network for DECs and DEGs, associated with the signaling pathway ‘glutamatergic synapse’. The network was constructed using Cytoscape 3.8.2 software. The nodes are designated the mRNAs or circRNAs. Each line connecting the nodes indicates the interaction of the corresponding mRNAs and circRNAs with common miRNAs. Accordingly, a different number of lines connecting the nodes indicates a different number of miRNAs, for the interaction with which circRNAs and mRNAs compete. The cut-off for circRNA-expression changes was 1.50. Only those circRNAs whose Padj < 0.05 were selected for analysis.