Table 1.

Modified miRNAs in BCC.

Nr	Ref	Expression	miRNA	Probe	Species	Role
1	Sand M. et al. [13,14]	upregulated	miRNA-17	tissue	human	pro-growth miRNA regulated in vitro by MAPK (mitogen-activated protein kinase)/ ERK-induced phosphorylation of TRBP (TAR-RNA binding protein)
			miRNA-18a miRNA-18b			cell proliferation and the suppression of apoptosis
			miRNA-19b miRNA-19b-1*			responsible for enhanced cell pro- liferation and the suppression of apoptosis
			miRNA-93			transcription factor E2F1 (E2 promoter binding factor 1) is a target gene of miRNA-93
			miRNA-106b			transcription factor E2F1 is a target gene of miRNA-106b
			miRNA-125a-5p			induces apoptosis
			miRNA-130a			regulatory effect on the apoptosis
			miRNA-181c miRNA-181c* miRNA-181d			targets NOTCH4( neurogenic locus notch homolog-4) and KRAS (Kirsten rat sarcoma virus)
			miRNA-182			negatively regulate human Forkheadbox O1 (FOXO1)
			miRNA-455-3p miRNA-455-5p miRNA-542-5p			not mentioned
		downregulated	miRNA-29c			downregulates DNA methyltransferases DNMT3A and DNMT3B
			miRNA-29c* miRNA-139-5p miRNA-140-3p			not mentioned
			miRNA-145			targets EGFR
			miRNA-572 miRNA-638 miRNA-2861 miRNA-3196			not mentioned
2	Heffelfinger et al. [36]	upregulated	let-7 family	tissue	human	involved in regulating cell proliferation
			miRNA-21			represses a variety of tumor suppressors such as PTEN (Phosphatase And Tensin Homolog) and PCDC4 (Programmed cell death protein 4)
			miRNA-148a miRNA-143 miRNA-378			not mentioned
3	Sonkoly E et al. [37]	downregulated	miRNA-203	tissue	human	downstream effector of the HH pathway and EGFR pathways. Potential therapeutic target for the treatment of BCC
4	Al-Eryani L et al. [39]	upregulated	miRNA-425-5p	tissue (arsenic induced lession)	human	Premalignant lesions progression to malignancy
			miRNA- 433
		downregulated	miRNA-29c			encoded in the last exon of C1orf132 (chromosome 1 open reading frame 132), and the transcript converts an unknown open reading frame
			miRNA-381 miRNA-452 miRNA487b miRNA-494 miRNA-590-5p			not mentioned
5	Hu P et al. [40]	downregulated	miRNA-34a	blood	human	can regulate cell cycle and inhibit the migration, spread and invasion of tumor cells
6	Sun H, Jiang P [41]	downregulated	miRNA-451a	tissue	human & mouse	limits cell proliferation by cell cycle arrest induction, suggesting the potential therapeutic target of miRNA-451a in BCC
7	Chang J et al. [42]	upregulated	miRNA197-5p	blood	human	Potential role in metastasis process
8	Wan C, Li Y [43]		miRNA-101	tissue	human	targets ING3
			miRNA-7b miRNA-141 miRNA-9 miRNA-200a miRNA-203 miRNA-7c miRNA-132 miRNA-203 miRNA-495 miRNA-385 miRNA-220a miRNA-30e miRNA-29b miRNA-103 miRNA-130a miRNA-144			not mentioned
9	Farzan SF et al. [44]	upregulated	miRNA-146a	blood	human	modulator of inflammatory immune responses, coordinating myeloid and lymphocyte function to impact aspects of both innate and adaptive immunity