Table 3.
Historical subtype prevalence of HIV patients in the Philippines based on area sequenced.
| First Author, yr [Ref] | Telan, 2013 [7] | Salvana, 2017[5] | Chen, 2019[9] | Current study[24] | ||
| Region Sequenced | Pro-RTA | Pro-RT | Near full- length | Pro-R (Stanford)D | Integrase (Stanford) | LTR-VIFB (jpHMM) |
| N | 163 | 81 | 23 | 85 | 85 | 71 |
| Years of Study Inclusion | 2008–2012C | Mar-Aug 2013 | 2015–2017 | 2017–2019 | ||
| Subtype (%) | ||||||
| CRF01_AE | 39.3∗ | 77 | 60.8 | 77.6 | 72.9 | 70.4 |
| B | 54 | 22 | 13 | 16.5 | 22.4 | 9.9 |
| CRF01_AE/BE | 21 | 2.3 | 0 | 14.1 | ||
| Other subtypes | 6.7 | 1 Subtype C | 1.2 Subtype A | 1.2 Subtype A | ||
| Other recombinantsF | – | 4.3 CRF01/07/B (n = 1) | 2.4 B/A1 (n = 1) G/CRF02_AG (n = 1) | 3.5 A/B (n = 1) B/CRF-3-AB (n = 1) CRF01_AG/G (n = 1) | 5.6 B/K (n = 1) CRF01/A1/B (n = 1) CRF01/A1 (n = 1) A1/G (n = 1) | |
HIV = human immunodeficiency virus.
A: region of HIV genome sequenced Pro-= protease, RT= reverse transcriptase, LTR=long terminal repeat, VIF = vial Infectivity factor
B: Average length ∼ 4500 nucleotides; partial LTR and VIF, entire GAG and POL genes. Consensus sequence incorporates the Pro-rt and Integrase data from VIroSeq analysis
C: Years that were sampled
D. Program used for these subtype designations
E: recombinant between CRF01_AE and subtype B
F. recombinants composed of other combinations other than just CRF01_AE and subtype B
∗
includes CRF02.