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. 2021 Dec 23;100(51):e28315. doi: 10.1097/MD.0000000000028315

Table 4.

POL gene subtype composition identified by jpHMM in recombinants (% of gene that is subtype B).

Gene
Sample Protease RT Rnase H Integrase§
10.ph17 AE AE/B (87.6%)1 B B
13.ph17 AE AE AE B (96%)
20.ph17 AE AE AE B (95.7%)
21.ph17 B B (∼86.7%)/AE AE AE
35.ph17 AE/B (∼57.5%) B (∼36.4%)/AE AE AE
36.ph17 AE/B (∼53.5%) B (38.2%)/AE AE AE
7.ph18 AE AE AE AE/B (32.5%)/AE2
17.ph18 AE AE/B (87.6%)3 B B
32.ph18 4 AE AE AE/B (86.9%) B (53.9%)/AE
27.ph17 AE AE AE/B (97.2%) B (55.8%)/A1
34.ph17 A1 A1 A1 A1
31.ph18 G G/A1 (48.6%5 A1 (80.6%)/G G

jpHMM POL location (HXB2 numbering) 2253–2550

jpHMM POL location (HXB2 numbering) 2550–3870

jpHMM POL location (HXB2 numbering) 3870–4230

§

jpHMM POL location (HXB2 numbering) 4230–5096

1subtype designation from 5’end - 3’end of gene; % calculated from breakpoints identified by jHMM

2breakpoints for subtype B portion in the the middle of the gene flanked by AE portions

3Stanford and Rega analysis classified p-RT together as B/A1

4breakpoints for subtype B portion in the middle of Rnase H and Integrase

5percentage of subtype in recombinants that do not have subytpe B.