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. 2021 Dec 23;100(51):e27868. doi: 10.1097/MD.0000000000027868

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Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

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Histone hyper-acetylation in the TNF-α promoter in cartilage from OA patients. Figure 4: ChIP assays were used to examine acetylated H3K9/K14 (A), H4K12 (B), HDAC1 (C), HAT1 (D), CBP (E) and p300 (F) occupancy in the region of the TNF-α promoter in normal and OA cartilage. Chromosome 15 and GAPDH were used as controls in the ChIP-qPCR experiments. The results were normalized to the percentage in the input control. Data are shown as the means ± SD. ∗P < .05, OA vs. normal. The data were obtained from 37 OA patients receiving knee replacement surgery and 13 samples of non-arthritic tissues obtained during amputation.