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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Biotechnol. 2020 Nov 21;70:29–35. doi: 10.1016/j.copbio.2020.10.007

Figure 2. Dietary Interventions that Modify Timing.

Figure 2

The schedule of different intermittent fasting approaches as compared to a daily 25% calorie restriction (CR). Time-restricted feeding (TRF*) does not restrict energy intake. Instead, food consumption is limited to certain hours per day to create an extended period of daily fasting. As its name implies, alternate-day fasting (ADF) alternates between unrestricted access and no food intake every other day. Alternate-day modified fasting (ADMF) is a version of ADF that allows a small amount (~25% of normal daily intake) of food on the fasting days. The 5:2 schedule is a less stringent version of ADMF where the low calorie days occur 2 days per week. The fasting mimicking diet (FMD) is a program where the low calorie days occur for 5 consecutive days each month and food is not restricted the remainder of the time (#). The shaded areas represent the daily % intake of total caloric needs, e.g. the fully shaded circles represent daily consumption of 100% of total caloric needs.