Table 1.
List of Transcription Factors included in further analysis. 44 Transcription factors included in the analysis with the dynamic Bayesian model, including VectorBase Transcript ID, Drosophila gene name, FBgn identifier, % identity (taken from VectorBase), putative function and network interactor summary KEGG/GO enrichment from this study (See S1 Table 1).
| Transcript ID | Gene Name | Homolog | % Identity | Role in Drosophila | Citation | Network Enrichment |
|---|---|---|---|---|---|---|
| AGAP000057-RA | shaven (sv) | FBgn0005561 | 34.12 | Sensory tissue development | Kavaler et al. 1999 (Kavaler et al., 1999) | None |
| AGAP000066-RA | Sox102F | FBgn0039938 | Neuronal development, behaviour and Wnt signalling | Li et al. 2017 (Li et al., 2017) | mTOR and ECM-receptor interaction | |
| AGAP000141-RA | CG31224 | FBgn0051224 | 17.03 | Unknown | Nuclear-related | |
| AGAP000547-RA | Rbsn-5 | FBgn0261064 | 42.29 | Endosome assembly | Morrison et al 2008 (Morrison et al., 2008) | Polarity, Wingless |
| AGAP000646-RA | Diminuitive (Dm, dMyc) | FBgn0262656 | 13.21 | Glucose and lipid metabolism, development | Parisi et al. 2013 (Parisi et al., 2013) | Sugar Metabolism, Miscellaneous Metabolism |
| AGAP000876-RA | achaete-scute complex (l(1)sc) | FBgn0002561 | 26.42 | Neuronal development, dopaminergic neurons | Stagg et al 2011 (Stagg et al., 2011) | Cuticle-related, Neuroactive ligand-receptor |
| AGAP001093-RA | kayak (kay) | FBgn0001297 | 30.06 | JNK signalling, wound healing, neuronal development | Ramet et al. 2002 (Rämet et al., 2002); Miotto et al. 2006 (Miotto et al., 2006) | RNA/DNA-related Processes |
| AGAP001156-RA | PSEA-binding protein 95kD (Pbp95) | FBgn0037540 | 13.89 | Small nuclear RNA activating complex | Li et al 2004 (Li et al., 2004) | Cytochrome P450s, Signalling Pathways |
| AGAP001388-RA | Doublesex-Mab related 93B (dmrt93B) | FBgn0038851 | 41.61 | Mouth development | Panara et al 2019 (Panara et al., 2019) | Taste/sense-related, Oxidoreductase Activity |
| AGAP001786-RA | Osa | FBgn0261885 | 36.83 | EGFR signalling | Terriente-Feliz and de Celis 2009 (Terriente-Félix and de Celis, 2009) | GSTs |
| AGAP001994-RA | Brahma associated protein 111kD (Bap111) | FBgn0030093 | 40.1 | Chromatin remodelling | Papoulas et al. 2001 (Papoulas et al., 2001) | Miscellaneous Metabolism, Cytochrome P450s, COEs |
| AGAP002082-RA | Squeeze (sqz) | FBgn0010768 | 35.47 | Neuronal development | Terriente-Feliz et al 2007 (Félix et al., 2007) | Ligase Activity |
| AGAP002155-RA | Hepatocyte nuclear factor 4 (Hnf4) | FBgn0004914 | 52.85 | Lipid mobilisation, glucose homeostasis and mitochondrial function | Palanker et al. 2009 (Palanker et al., 2009); Barry and Thummel 2016 (Barry and Thummel, 2016) | Glyoxylate Metabolism, Transcription Coactivator |
| AGAP002352-RB | p53 | FBgn0039044 | 14.2 | Genotoxic stress response | Brodsky et al. 2004 (Brodsky et al., 2004) | Carbon metabolism |
| AGAP002773-RA | Stripe (sr) | FBgn0003499 | Muscle development | Lee et al. 1995 (Lee et al., 1995) | Steroid biosynthesis | |
| AGAP002902-RA | Medea (Med) | FBgn0011655 | 52.42 | Muscle development through BMP and dpp Pathways | Wisotzkey et al. 1998 (Wisotzkey et al., 1998) | Metabolism-related |
| AGAP002920-RA | CG17829 | FBgn0025635 | 17.84 | Unknown | Protein Complex Binding, DNA/RNA processes | |
| AGAP002954-RA | Cell division cycle 5 (Cdc5) | FBgn0035136 | 63.63 | Spliceosome | Herold et al. 2009 (Herold et al., 2009) | Notch Signalling, Apoptosis |
| AGAP003117-RA | Capicua (cic) | FBgn0262582 | 19.37 | EGFR, Torso and TOLL signalling | Astigarraga et al. 2007 (Astigarraga et al., 2007); Papagianni et al.2018 (Papagianni et al., 2018) | Glycan degradation |
| AGAP003449-RA | Rootletin (Root) | FBgn0039152 | 46.08 | Hearing, touch and taste | Chen et al. 2015 (Chen et al., 2015) | Steroid Biosynthesis, Receptor-related activity, Cytochrome P450s |
| AGAP003669-RA | Drop (Dr) | FBgn0000492 | 61.4 | Eye and nerve development | Tearle et al. 1994 (Tearle et al., 1994) | Circadian Pathway |
| AGAP004864-RA | Protein on ecdysone puffs (Pep) | FBgn0004401 | 38.87 | Hsp70 response through hnRNP complex | Hamann et al. 1998 (Hamann and Strätling, 1998) | Response to xenobiotics |
| AGAP004990-RA | Multiprotein bridging factor 1 (mbf1) | FBgn0262732 | 74.15 | Co-activator to induce stress-response genes | Jindra et al. 2004 (Jindra et al., 2004) | Translation-related Processes |
| AGAP005437-RA | Inverted repeat binding protein 18 kDa (Irbp18) | FBgn0036126 | Inhibitor of the conserved stress response protein dATF4/Crc | Blanco et al 2020 (Blanco et al., 2020) | Fatty Acid-related | |
| AGAP005551-RA | Rabaptin-5-associated exchange factor for Rab5 (Rabex-5) | FBgn0262937 | 37.75 | Ras pathway homeostasis | Yan et al. 2010 (Yan et al., 2010) | Apoptosis |
| AGAP005641-RA | CG9705 | FBgn0036661 | 54.78 | Sensory neurons | Iyer et al. 2013 (Iyer et al., 2013) | Protein Sorting, Response to DNA-damage |
| AGAP005655-RA | Cylce (Cyc) | FBgn0023094 | 35.25 | Circadian rhythm | Rutila et al. 1998 (Rutila et al., 1998) | UGTs, Hormone Biosynthesis |
| AGAP006022-RA | Methoprene tolerant (Met) | FBgn0002723 | 21.2 | Juvenile hormone binding | Jindra et al. 2015 (Jindra et al., 2015) | Oxidative Phosphorylation |
| AGAP006061-RA | Ken | FBgn0000286 | 5.92 | JAK/STAT pathway | Arbouzova et al. 2006 (Arbouzova et al., 2006) | GTPase Activity, Vesicle-related, Actin-related |
| AGAP006392-RA | CG4617 | FBgn0029936 | 38.58 | Unknown | Autophagy | |
| AGAP006601-RA | MEP-1 | FBgn0035357 | 31.69 | Chromatin remodelling | Reddy et al. 2010 (Reddy et al., 2010) | Peroxisome, CSPs |
| AGAP006642-RA | Defective proventriculus (dve) | FBgn0020307 | 47.98 | Mitochondrial reactive oxygen species modulator | Baqri et al. 2014 (Baqri et al., 2014) | Behavioural-related, Neuron-related |
| AGAP006736-RA | Sugarbabe (sug) | FBgn0033782 | 28.24 | Regulation of lipid and carbohydrate metabolism | Varghese et al. 2010 (Varghese et al., 2010) | P450, IMD-pathway |
| AGAP006747-RA | Relish (REL2) | FBgn0014018 | 24.12 | Immune response | Dushay et al. 1996 (Dushay et al., 1996) | Transferase, Dendrite-related, CSPs |
| AGAP009444-RA | Suppressor of variegation 205 (Su(var)205) | FBgn0003607 | 23.47 | Hsp70 response through activation of euchromatic genes | Piacentini et al. 2003 (Piacentini et al., 2003) | Ribosome-related, Hippo signalling |
| AGAP009494-RA | Ets at 21C (Ets21C) | FBgn0005660 | 34.25 | Stress inducible transcription factor through JNK | Mundorf et al. 2019 (Mundorf et al., 2019) | Behaviour-related, Neuronal, JAK/STAT |
| AGAP009515-RA | REL1 | FBgn0260632 | 38.96 | Toll pathway | Gross et al. 1999 (Gross et al., 1999) | Vesicle-related Transport, Mitophagy, Toll pathway |
| AGAP009662-RA | Kruppel Homolog 1 (Kr-h1) | FBgn0028420 | 36.47 | 20-hydroxyecdysone linked | Pecasse et al. 2000 (Pecasse et al., 2000) | TCA-cycle |
| AGAP009676-RA | Chameau (chm) | FBgn0028387 | 34.66 | JNK signalling | Miotto et al. 2006 (Miotto et al., 2006) | Transmembrane Signalling, Behavioural-related, Neuronal |
| AGAP009888-RA | CG33695 | FBgn0052831 | 53.3 | Unknown | Hippo Signalling, COEs | |
| AGAP009899-RA | klumpfuss (klu) | FBgn0013469 | 42.86 | Cell death, mitochondrial function, EGFR signalling | Protzer etl al. 2008 (Protzer et al., 2008); Chen et al. 2008 (Chen et al., 2008) | Morphogenesis, Drug Metabolism, UGTs, GSTs |
| AGAP009983-RA | Net | FBgn0002931 | 35.88 | EGFR signalling | Terriente-Feliz and de Celis 2009 (Terriente-Félix and de Celis, 2009) | MAPK/Notch Signalling |
| AGAP010405-RA | Maf-S | FBgn0034534 | 63.7 | Reactive oxygen species stress response | Misra et al. 2011 (Misra et al., 2011) | Respiration-related, Insulin-related |
| AGAP012389-RA | Pangolin (Pan) | FBgn0085432 | 24.47 | Wingless signalling | Brunner et al. 1997 (Brunner et al., 1997) | Wnt-signalling, COEs |