Table 1.

Summary of outcome from major studies

References	Study design	Setting	No. of patients	Median F/U (years)	5 year LC (%					5 year DFS (%)	5 year OS (%)
Yang et al. [5]	Randomized	LSS alone	71	17.9	78 (10 year)	High grade		68 (10 year)	Low grade	Not reported	74 (10 year)
		LSS + post-op EBRT	70		100 (10 year)			95 (10 year)			75 (10 year)
O'Sullivan et al. [17]	Randomized	Pre-op EBRT	94	3.3			p = 0.791			Not reported	p = 0.791
		Post-op EBRT	96
Jebsen et al. [8]	Retrospective	LSS alone	598	5	28 (Intralesional margins)		74 (Marginal margins)	87 (Marginal margins)		Not reported	Not reported
		LSS + EBRT (pre or post)	381		62 (Intralesional margins)		81 (Marginal margins)	93 (marginal margins)
Pisters et al. [6]	Prospective randomized	LSS alone	164	6.3			69			81	Not reported
		LSS + BRT					82			84
Sampath et al. [19]	Retrospective	Pre-op EBRT	293	5.3			93			Not reported	65
		Post-op EBRT	528				87				60
Wang et al. [27]	Prospective phase II	Pre-op EBRT + LSS	79	3.6			94 (2 year)			61.5 (2 year)	80.6 (2 year)
Koshy et al. [10]	Retrospective	LSS alone	3.689	Not reported			Not reported			Not reported	73 (3 year)
		LSS + EBRT (pre or post)	3.271								63 (3 year)
Alektiar et al. [21]	Retrospective	LSS + EBRT (pre or post)	41	3			84			Not reported	64

EBRT: external beam radiotherapy, LSS: limb sparing surgery