Table 2.

Summary of side effects from major studies

References	Study design	Setting	No. of patients	Median F/U (years)	Wound complications (%)	Late toxicity grade ≥ 2 (%)
O'Sullivan et al. [17]	Randomized	Pre-op EBRT	94	3.3	35	Not reported
		Post-op EBRT	96		17
Davis [18]	Randomized	Pre-op EBRT	73	Not reported	Not reported	31.5 Fibrosis	15.1 Edema	17.8 Joint stiffness
		Post-op EBRT	56			48.2	23.2	23.2
Wang et al. [22]	Prospective phase II	Pre-op EBRT + LSS	79	3.6	36.6	10.5
Beane et al. [7]	Randomized	LSS alone	71	17.9	20	4 Bone fracture	12 Edema
		LSS + post-opEBRT	70		27	10	25
Alektiar et al. [21]	Retrospective	LSS + EBRT (pre or post	41	3	19.5	4.8 Bone fracture	12 Edema	17.1 Joint stiffness

EBRT: external beam radiotherapy; LSS: limb sparing surgery