Fig. 2.

Comparison of the molecular spectrum of pre-outbreak Omicron mutations and spectra of mutations known to accumulate in humans. A: The molecular spectrum of viral mutations that accumulated in humans (the hSCV2 spectrum). B: The molecular spectra of pre-outbreak and post-outbreak Omicron mutations. P values were given by G-tests against the hSCV2 spectrum. C: The distribution of P values (given by G-tests) of 100 pseudo samples that were downsampled from the hSCV2 spectrum. The number of mutations (n) of each pseudo sample was equal to 45. SARS-CoV-2 data of Patient 1 were retrieved from Kemp et al. (2021), and those of Patients 2 and 3 were retrieved from Truong et al. (2021).