Table 3.
Distributions of the Types of Genetic Biomarkers and the Relevant Genomes for Genetic Biomarkers Contained in Clinical Pharmacogenetic Recommendations by Therapeutic Area.
| Therapeutic Area | Genetic Biomarker Type | Relevant Genome for Genetic Biomarker | |||
|---|---|---|---|---|---|
| Genetic Variation | Gene Expression | Germline | Somatic | Pathogen (Viral) | |
| Oncology | 105 (48.4%) | 112 (51.6%) | 34 (15.7%) | 183 (84.3%) | 0 (0%) |
| Hematology | 71 (88.8%) | 9 (11.3%) | 13 (16.3%) | 67 (83.8%) | 0 (0%) |
| Psychiatry | 65 (100%) | 0 (0%) | 65 (100%) | 0 (0%) | 0 (0%) |
| Cardiovascular | 43 (100%) | 0 (0%) | 43 (100%) | 0 (0%) | 0 (0%) |
| Anesthetics | 37 (100%) | 0 (0%) | 37 (100%) | 0 (0%) | 0 (0%) |
| Neurology | 33 (100%) | 0 (0%) | 33 (100%) | 0 (0%) | 0 (0%) |
| Antivirals | 26 (100%) | 0 (0%) | 23 (88.5%) | 0 (0%) | 3 (11.5%) |
| Anti-Infectives | 19 (100%) | 0 (0%) | 19 (100%) | 0 (0%) | 0 (0%) |
| Gastroenterology | 19 (100%) | 0 (0%) | 19 (100%) | 0 (0%) | 0 (0%) |
| All Other TAs | 66 (98.5%) | 1 (1.5%) | 67 (100%) | 0 (0%) | 0 (0%) |
| Total | 484 (79.9%) | 122 (20.1%) | 353 (58.3%) | 250 (41.3%) | 3 (0.5%) |
All data are presented as follows: counts (percentages). The “all other therapeutic areas” category includes pulmonary, rheumatology, endocrinology, analgesic, urology, immunosuppressant, medical countermeasure, metabolism, reproduction, addiction, and bone products.
Abbreviations: TA = therapeutic area