Skip to main content
. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Immunol. 2021 Nov 24;208(1):16–26. doi: 10.4049/jimmunol.2100643

Figure 6. B6.DR1 mice treated with DR1-CII CAR T cells produce significantly less autoantibody.

Figure 6.

Plasma was collected from mice in the arthritis experiment in Figure 5 and tested for the presence of anti-CII autoantibody. All mice were immunized with CII/CFA to induce autoimmunity to CII, and then treated with DR1-CII CAR T cells or control NT CD8+ T cells, or left untreated as indicated. A bead based ELISA using CII coupled Luminex beads was used to quantitate the antibody. A standard curve produced using affinity purified anti-CII antibody was used to calculate the quantity of autoantibody measured. ★ indicates p ≤ 0.02 by Student’s t-test.