Table 1.

Cytokines produced by DR1 CAR T cells following stimulation with antibody to HLA-DR1 or antibodies to CD3 and CD28.

		Cytokine, pg/ml
CAR T cell	Stimulation	TNF α	IFNγ	IL-6	IL-10	IL-17A
DR1-CII	anti-DR1	5583.9 ± 1431.5	>15,000	54.5 ± 8.3	132.5 ± 35.3	2.6 ± 0.7
DR1-CII	anti-CD3/CD28	5650.2 ± 538.7	>15,000	70.7 ± 6.1	184.2 ± 37.1	2.7 ± 0.6
DR1 CII	none	29.0 ± 14.8	13.4 ± 1.9	–*	34.6 ± 18.7	– *
DR1-HA	anti-DR1	145.0 ± 20.2	>15,000	8.5 ± 0.9	122.9 ± 23.4	2.5 ± 0.5
DR1-HA	anti-CD3/CD28	3381.0 ± 1008.5	>15,000	40.4 ± 3.2	366.7 ± 31.1	3.8 ± 0.4
DR1-HA	none	106.6 ± 99.4	29.9 ± 12.2	4.3 ± 3.8	133.0 ± 127.2	3.5 ± 2.6

^*Below detection level