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Endogenous production of Very long chain saturated fatty acids (VLSFAs). VLSFAs are produced from 18 : 0 by elongases in the ELOVL (elongation of very long chain fatty acids) family of enzymes. Seven ELOVL enzymes exist in humans and overlap in the elongation steps they can catalyze. The 18 : 0 can come from 16 : 0 or from the diet. The VLSFAs are in low abundance unlike 18 : 0 and 16 : 0, and only a small proportion of 18 : 0 is elongated to 20 : 0 and longer saturates.
