Table 2.

Antibody Response of the Vaccine Recipient at Pre-Vaccination, Post-Vaccination Dose 1 and Post-Vaccination Dose 2

Antibody Response Measured by ODR	Pre-Vaccination	Post-Vaccination D-1	Post-Vaccination D-2	p-value
Median (IQR)	0.69 (0.43–0.92)	5.43 (4.32–6.98)a	10.90 (9.02–11.90)a,b	<0.001*
Response category	n (%)	n (%)	n (%)
Negative (ODR <0.8)	496 (64.5)	1 (0.10)	–
Borderline (ODR 0.8–1.1)	273 (35.5)	–	–
Positive (ODR >1.1)	–	768 (99.9)	769 (100.00)

Notes: *Friedman’s two-way analysis of variance (ANOVA) with post-hoc analysis using Wilcoxon signed rank test and Bonferroni adjustments (^ap <0.001 compared to pre-vaccination, ^bp<0.001 compared to post-vaccination D-1).

Abbreviations: D-1, Dose 1; D-2, Dose 2; ODR, optical density ratio; IQR, interquartile Range.