. 2021 Dec 19;14:5491–5500. doi: 10.2147/IDR.S335414

Table 4.

Estimated Marginal Means of Patients at Pre-Vaccination, Post-Vaccination Dose 1 and Post-Vaccination Dose 2 Time Points by Age, Sex and Comorbidities

Variables	Categories	Pre-Vaccination Mean ±SE	Post-Vaccination D-1 Mean ±SE	Post-Vaccination D-2 Mean ±SE	p-value
Variables	Categories	Pre-Vaccination Mean ±SE	Post-Vaccination D-1 Mean ±SE	Post-Vaccination D-2 Mean ±SE	Interaction (Time x Group)	Pre-Vaccination v Post-Vaccination D-1	Post-Vaccination D-1 v Post-Vaccination D-2
Age (years)	18–55	0.66 ±0.01	5.75 ±0.07	10.39 ±0.07	<0.001	<0.001	0.001
	>55	0.70 ±0.03	4.91 ±0.18^a	8.99 ±0.19^a	<0.001	<0.001	0.001
Sex	Female	0.67 ±0.02	5.61 ±0.10	10.18 ±0.11	0.855	0.689	0.876
	Male	0.67 ±0.01	5.67 ±0.08	10.25 ±0.09	0.855	0.689	0.876
Comorbidity	Present	0.67 ±0.01	5.69 ±0.08	10.38 ±0.09	0.003	0.412	0.003
	Absent	0.67 ±0.02	5.58 ±0.11	9.93 ±0.12^a	0.003	0.412	0.003

Notes: Antibody response measured in optical density ratio (ODR); P-value for interaction was determined by Huynh-Feld t test as sphericity assumption was violated. Comparison between time-points was carried out using ANOVA, and post hoc analysis of simple main effect was carried out when there is significant interaction using Bonferroni adjustments (^ap<0.001 between categories).

Abbreviations: D-1, Dose 1; D-2, Dose 2.