Table 1.
More relevant PROs validated for use in the assessment of CKD-aP
| PRO | Symptoms recalling | Strengths/limitations | |
|---|---|---|---|
| Unidimensional | |||
| VAS | Worst itch in the previous 24 h | Simple and fast/highly subjective | |
| NRS | Worst itch in the previous 24 h | Simple and fast/highly subjective | |
| VRS | Worst itch in the previous 24 h | Simple and fast/highly subjective | |
| Q20 KDQOL-SF | Evaluation of the last 4 weeks | Used in large studies/not validated as a severity measure | |
| Multidimensional | |||
| 5D itch scale | 14 days | Validated to analyse the course of itch/time-consuming | |
| Skindex-10 | 7 days | Validated to evaluate CKD-aP intensity/time-consuming | |
| Dedicated to evaluating sleep | |||
| SADS | At administration | Fast/less used in studies | |
| Itch MOS | Previous week | Assesses exclusively sleep disturbance |