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. 2021 Dec 10;12:796565. doi: 10.3389/fphar.2021.796565

FIGURE 4.

FIGURE 4

Transcriptome Profiling Analysis for the rat retina across the control (CON), diabetic model rat (DM), 200 mg/kg curcumin treatment (CUR), long-acting insulin treatment (INS), and 200 mg/kg curcumin and long-acting insulin treatment (CUR + INS) groups. (A) Using the 1% agarose gel electrophoresis to examine the integrity of RNA in different groups. Lane M: RNA marker; Lanes 1, 2, and 3: three CON samples; Lanes 4, 5, and 6: three DM samples; Lanes 7, 8, and 9: three CUR samples; Lanes 10, 11, and 12: three INS samples; Lanes 13, 14 and 15: three (CUR + INS) samples. (B) the three-dimensional scattered plots of the principal component analysis, which indicated a distinct separation among five different groups. PC, principal component. Heat maps showing the whole differentially expressed genes from the DM-vs-CON (C), CUR-vs-DM (D), INS-vs-DM (E), and (CUR + INS)-vs-DM (F) comparisons. Each column represents an individual retinal sample. Red indicates upregulated, and blue downregulated genes.