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. 2021 Dec 10;12:796565. doi: 10.3389/fphar.2021.796565

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Copyright © 2021 Xie, Chen, Chen, Huang, Peng, Tian, Wu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top 10 most significantly Gene Ontology (GO) functional enrichment analysis terms of differentially expressed genes in three types of functions: biological process (BP), cellular component (CC), and molecular function (MF). Bubble diagram showing the enriched GO results from the DM-vs-CON (A), CUR-vs-DM (B), INS-vs-DM (C), and (CUR + INS)-vs-DM (D) comparisons. Y-axis: the significantly GO category entries; X-axis: the Ratio of the number of genes enriched by differentially expressed genes to the GO item and the number of genes enriched by all genes to the GO item. The color of the bubble represents the enrichment significance p-value, and the size of the bubble represents the number of differentially expressed genes.