Table 2.
Summary of noncoding RNAs involved in osteosarcoma metastasis.
| Author | Noncoding RNA | Pro/anti | Related genes or pathways |
|---|---|---|---|
| microRNA | |||
| Gao et al. (270) | miR-17 | Pro | PTEN↓ |
| Ding et al. (271) | miR-18a | Anti | MED27, Akt↓ |
| Sun et al. (272) | miR-19 | Pro | SOCS6↓; JAK2/STAT3↑ |
| Xin et al. (273) | miR-22 | Anti | ACLY, lipogenesis↓ |
| He et al. (274) | miR-23a | Anti | RUNX2, CXCL12↓ |
| Chen et al. (275) | miR-25 | Anti | SOX4, EMT↓ |
| Lu et al. (276) | miR-26a | Anti | Jagged1/Notch, ALDH, stemness↓ |
| Zhang et al. (277) | miR-30a | Anti | RUNX2↓ |
| Tao et al. (278) | miR-30a-5p | Anti | FOXD1↓ |
| Zhao et al. (279) | miR-34a | Anti | SIRT1, c-MET, CDK6↓ |
| Liu et al. (280) | miR-92a | Anti | Notch1↓ |
| Yu et al. (281) | miR-124 | Anti | TGF-β/Akt/GSK-3β/SNAIL-1↓ |
| Liu et al. (282) | miR-125b | Anti | STAT3↓ |
| Bao et al. (283) | miR-134 | Anti | – |
| Li et al. (284) | miR-137 | Anti | FXYD6↓ |
| Shi et al. (285) | miR-139-5p | Anti | DNMT1↓ |
| Gu et al. (286) | miR-140 | Anti | – |
| Xiao et al. (287) | miR-140 | Anti | HDAC4↓ |
| Wang et al. (288) | miR-144 | Anti | ROCK1, ROCK2↓ |
| Li et al. (289) | miR-145 | Anti | CDK6↓ |
| Yang et al. (290) | miR-148a | Anti | ROCK1↓ |
| Zhou et al. (291) | miR-154 | Anti | Wnt5a↓ |
| Jiang et al. (292) | miR-181a | Pro | PTEN↓ |
| Zhang et al. (293) | miR-186-5p | Anti | FOXK1, EMT↓ |
| Pan et al. (294) | miR−188 | Anti | SOX4↓ |
| Pu et al. (295) | miR-193a-3p; miR-193a-5p | Anti | Rab27B, SRR↓ |
| Li et al. (296) | miR-204-5p | Anti | EBF2↓ |
| Jiang et al. (297) | miR-208b | Anti | ROR2↓ |
| Liu et al. (298) | miR-210 | Pro | – |
| Luo et al. (299) | miR-212 | Anti | SOX4↓ |
| Xu et al. (300) | miR-214 | Pro | LZTS1↓ |
| Sun et al. (301) | miR-217 | Anti | – |
| Jiang et al. (302) | miR-329 | Anti | Rab10↓ |
| He et al. (303) | miR-363 | Anti | PDZD2, EMT↓ |
| Xu et al. (304) | miR-372-3p | Anti | FXYD6↓ |
| Li et al. (305) | miR-379 | Anti | PDK1↓ |
| Zhao et al. (306) | miR-410 | Anti | VEGF↓ |
| Yang et al. (307) | miR-425-5p | Anti | MALAT1, TUG1, Wnt/β-catenin↓ |
| Yuan et al. (308) | miR-451 | Anti | – |
| Yuan et al. (309) | miR−494 | Anti | CDK6↓ |
| Qi et al. (310) | miR−496 | Anti | eIF4E↓ |
| Pang et al. (311) | miR−497 | Anti | – |
| Cai et al. (312) | miR−590−5p | Anti | KLF5↓ |
| Liu et al. (313) | miR−598 | Anti | – |
| Ma et al. (314) | miR−603 | Pro | BRCC2↓ |
| Wang et al. (315) | miR−643 | Anti | ZEB1↓ |
| Zhang et al. (316) | miR−663a | Anti | ZBTB7A↓; LncRNA GAS5↑ |
| Liu et al. (317) | miR−873 | Anti | HOXA9, Wnt/β−catenin↓ |
| Tanushree et al. (318) | miR−874 | Anti | CCNE1↓ |
| Zhong et al. (319) | miR−1270 | Anti | – |
| Yuan et al. (320) | miR−1908 | Anti | PTEN↓ |
| Long noncoding RNA | |||
| Shi et al. (321) | AFAP1-AS1 | Pro | RhoC/ROCK1/p38MAPK/Twist1↑ |
| Li et al. (322) | AFAP1-AS1 | Pro | miR−4695−5p↓ TCF4−Wnt/β−catenin↑ |
| Lu et al. (323) | CASC2 | Anti | – |
| Zhao et al. (324) | EPIC1 | Anti | MEF2D↓ |
| Zhu et al. (325) | FOXF1-AS1 | Pro | FOXF1/MMP2/9↑ |
| Sun et al. (326) | FGFR3-AS1 | Pro | FGFR3↑ |
| Ren et al. (327) | FOXD2-AS1 | Pro | EZH2, p21↓ |
| Ye et al. (328) | GAS5 | Anti | miR-221, EMT↓; ARHI↑ |
| Qu et al. (329) | HOXD-AS1 | Pro | STAT3, MMP2↑ |
| Wang et al. (330) | HOTAIR | Pro | MMP2/9↑ |
| Gu et al. (331) | LINC00858 | Pro | miR-139↓; CDK14↑ |
| Zhang et al. (332) | LINC01116 | Pro | miR-520a-3p↓; IL6R, JAK/STAT↑ |
| Han et al. (333) | LUCAT1 | Pro | miR-200c↓; ABCB1↑ |
| Chen et al. (334) | MALAT1 | Pro | miR-129-5p↓; RET-PI3K/Akt, stemness↑ |
| Dong et al. (335) | Mal. AT1 | Pro | p85α, PI3K/Akt, MMP9, PCNA↑ |
| Duan et al. (336) | MALAT1 | Pro | miR−34a↓; cyclin D1↑ |
| Li et al. (337) | miR210HG | Pro | miR-503↓; EMT, N-cadherin, vimentin↑ |
| Hu et al. (338) | NEAT1 | Pro | miR-34c↓ |
| Ye et al. (339) | NNT-AS1 | Pro | – |
| Zhu et al. (340) | ODRUL | Pro | miR-3182↓; MMP2↑ |
| Wang et al. (341) | SNHG1 | Pro | miR-326↓; NOB1 |
| Jiang et al. (342) | SNHG1 | Pro | miR-577↓; WNT2B/Wnt/β-catenin, EMT↑ |
| Deng et al. (343) | SNHG7 | Pro | miR-34a↓; TGF-β, SMAD4, EMT↑ |
| Yang et al. (344) | TP73-AS1 | Pro | miR-142↓; Rac1↑ |
| Wang et al. (345) | TUG1 | Pro | miR-153↓ |
| Yang et al. (346) | XIST | Pro | miR-195-5p↓; YAP↑ |
| Zhang et al. (347) | XIST | Antia | miR-21-5p, EMT↓; PDCD4↑ |
| Circular RNAs | |||
| Liu et al. (348) | CircFAT1 | Pro | miR-375↓; YAP 1↑ |
Studies using animal models of osteosarcoma metastasis are included.
Pro, the target gene promotes metastasis; anti, the target gene inhibits metastasis; “↑” upregulation; “↓” downregulation.
a
The results in this article is contrary to that of the previous one.