Table 2.
Univariate and Multivariate Cox Analysis in MCB Patients
| Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age, years | ||||
| <72 | ||||
| 72–82 | 3.384(2.513–4.557) | <0.001 | 3.464(2.551–4.704) | <0.001 |
| >82 | 8.926(6.595–12.081) | <0.001 | 7.766(5.644–10.685) | <0.001 |
| Tumor size, mm | ||||
| <13.0 | ||||
| 13.0–27.0 | 1.599(1.185–2.159) | 0.002 | ||
| >27.0 | 2.710(1.985–3.701) | <0.001 | ||
| Race | ||||
| White | ||||
| Black | 0.573(0.303–1.082) | 0.086 | ||
| Other | 1.358(0.906–2.036) | 0.138 | ||
| Grade | ||||
| I | ||||
| II | 1.023(0.797–1.313) | 0.857 | ||
| III | 1.610(0.964–2.690) | 0.069 | ||
| IV | 2.348(0.329–16.780) | 0.395 | ||
| AJCC | ||||
| I | ||||
| II | 1.862(1.447–2.395) | <0.001 | 2.431(1.099–5.375) | 0.028 |
| III | 2.261(1.345–3.801) | 0.002 | 2.169(0.820–5.740) | 0.119 |
| IV | 18.298(11.708–28.597) | <0.001 | 5.691(1.746–18.550) | 0.004 |
| T stage | ||||
| T1 | ||||
| T2 | 1.882(1.460–2.425) | <0.001 | 0.698(0.318–1.531) | 0.370 |
| T3 | 2.287(1.493–3.503) | <0.001 | 0.657(0.290–1.484) | 0.312 |
| T4 | 7.216(4.159–12.519) | <0.001 | 1.891(0.705–5.071) | 0.205 |
| N stage | ||||
| N0 | ||||
| N1 | 1.336(0.898–1.988) | 0.154 | ||
| N2 | 2.094(0.864–5.079) | 0.102 | ||
| N3 | 2.763(1.028–7.423) | 0.044 | ||
| M stage | ||||
| M0 | ||||
| M1 | 13.926(9.065–21.395) | <0.001 | ||
| Surgery | ||||
| No | ||||
| Yes | 0.119(0.086–0.166) | <0.001 | 0.357(0.233–0.546) | <0.001 |
| Radiotherapy | ||||
| No | ||||
| Yes | 0.388(0.388–0.302) | <0.001 | 0.616(0.470–0.807) | <0.001 |
| Chemotherapy | ||||
| No | ||||
| Yes | 0.650(0.434–0.973) | 0.036 | ||
| Bone metastasis | ||||
| No | ||||
| Yes | 15.610(9.537–25.550) | <0.001 | 3.490(1.318–9.238) | 0.012 |
| Brain metastasis | ||||
| No | ||||
| Yes | 12.708(4.067–39.709) | <0.001 | ||
| Liver metastasis | ||||
| No | ||||
| Yes | 14.352(4.568–45.093) | <0.001 | ||
| Lung metastasis | ||||
| No | ||||
| Yes | 8.308(3.916–17.623) | <0.001 | ||
| ER | ||||
| Negative | ||||
| Positive | 0.584(0.241–1.414) | 0.233 | ||
| PR | ||||
| Negative | ||||
| Positive | 0.713(0.494–1.031) | 0.072 | ||
| HER2 | ||||
| Negative | ||||
| Positive | 0.684(0.384–1.220) | 0.198 | ||
| Marital status | ||||
| No | ||||
| Yes | 0.509(0.399–0.649) | <0.001 |
Abbreviations: MCB, mucinous carcinoma of the breast; HR, hazard ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor 2-neu.