Table 2. Other EMT TFs.
| EMT TFs | Effect on EMT (cell/tissue types tested) | Direct target genes (cell/tissue types tested) | ||
|---|---|---|---|---|
| EMT I | EMT II | EMT III | ||
| E12/E47 | - | Inducer (renal proximal tubular epithelial cells, MDCK cells) | Inducer (colon cancer metastasis) | CDH1 (MDCK cells) |
| KLF4 | - | - | Suppressor (lung epithelial cells, nasopharyngeal carcinoma cells, hepatocellular carcinoma cells, lung cancer cells, human endometrial carcinoma cells, pancreatic cancer cells, colorectal cancer cells) | CDH1 (nasopharyngeal carcinoma cells) |
| Reversal of EMT (gastric cancer cells) | Serine/threonine kinase 33 (gastric cancer cells) | |||
| KLF8 | - | - | Inducer (MDCK, MCF-10A, Panc-1, gastric cancer cell line SGC7901, breast cancer cells) | CDH1 (breast cancer cells) |
| KLF10 | - | - | Suppressor (A549, Panc-1) | SLUG (A549, Panc-1) |
| FOXC1 | - | - | Inducer (esophageal cancer, nasopharyngeal cancer, basal like breast cancer, glioma, cervical cancer, and hepatocellular carcinoma) | FGFR1 (NMuMG cells), ZEB2 (esophageal cancer cells) |
| FOXC2 | - | - | Inducer (mouse mammary carcinoma cell, mammary epithelial cells, basal-type human breast cancer cells, ovarian cancer cells) | ZEB1 (breast cancer cells) |
| FOXQ1 | - | - | Inducer (basal-like breast cancer, Mammary, bladder and colon epithelial cells, gastric cancer cells) | CDH1 (breast cancer cells), CDH2 (breast cancer cells) |
| FOXK1 | - | - | Inducer (colon cancer cells) | ND |
| FOXG1 | - | - | Inducer (human hepatocellular carcinoma cells) | ND |
| FOXM1 | - | - | Inducer (non-small cell lung cancer, kidney cells) | ND |
| FOXF2 | - | - | Suppressor (basal-like breast cancer cells, triple-negative breast cancer cells) | TWIST1, FOXC2, FOXQ1 (basal-like breast cancer cells) |
| FOXN2 | - | - | Suppressor (breast cancer cells) | SLUG (breast cancer cells) |
| FOXO3a | - | - | Suppressor (prostate cancer cells) | ND |
| SOX4 | - | - | Inducer (mammary epithelial cells, breast cancer cells, triple-negative breast cancer cells, lung carcinoma cells, gastric cancer cells, prostate cancer calls, renal cancer cells) | EZH2 (NMuMG cells), ADAM28 (human breast and lung carcinoma cells), CDH2 (triple-negative breast cancer cells) |
| SOX9 | Inducer (neural crest development) | Inducer (liver fibrosis) | Inducer (thyroid cancer cells, prostate cancer cells, non-small cell lung cancer cells, gastric cancer cells, human oral squamous carcinoma cells, gastric carcinoma cells) | ND |
| SOX11 | - | - | Inducer (breast cancer cells) | SLUG (breast cancer cells) |
| Promoted epithelial–mesenchymal hybrid characteristics (ER-negative DCIS.com breast cancer cell) | ND | |||
| RUNX1 | - | Inducer (renal fibrosis) | Inducer (colorectal cancer cells, kidney epithelial cells) | p110δ (renal tubular epithelial cells) |
| RUNX2 | Inducer (chicken atrioventricular canal) | Inducer (lung fibrosis) | Inducer (thyroid cancer cells, hepatocellular cancer cells, renal cell carcinoma cells, non-small cell lung cancer cells) | ND |
| GATA4 | Inducer of cell migration (gastrulation) | - | Inducer (nasopharyngeal carcinoma cell) Induce moderate MET (hepatocellular carcinoma cells) |
SLUG (nasopharyngeal carcinoma cell) |
| GATA6 | Serpent, ortholog of human GATA6 acts as inducer of EMT in Drosophila endoderm. Inducer of cell migration (gastrulation) |
Inducer (canine kidney cells) | Inducer (cholangiocarcinoma cells, breast cancer cells) Suppressor (pancreatic cancer cells) |
MUC1 (cholangiocarcinoma cells), SNAI2 (beast cancer cells), crumbs (Drosophila endoderm, canine kidney cells) CDH1 and VIM (pancreatic cancer cells) |
| WT1 | Inducer of MET in early kidney development; Inducer (epicardial cells); suppressor (human adult epicardial cells) | Inducer (lung fibrosis) | Inducer (ovarian cancer cells) Promoted epithelial–mesenchymal hybrid state (clear cell renal cell carcinoma) |
SNAI1 (epicardial cells), CDH1 (epicardial cells, ovarian cancer cells), SLUG (epicardial cells) |
| Goosecoid | Inducer of cell migration (gastrulation) | - | Inducer (breast cancer cells, hepatocellular carcinoma cells) | ND |
| Six1 | - | Inducer (lung epithelial cell fibrosis) | Inducer (mammary carcinoma cells, colorectal cancer cells, cervical cancer cells, lung epithelial cells, immortalized human keratinocytes) | ND |
| Prrx1 | Inducer (chicken embryo) | Inducer (hepatic fibrosis, canine kidney cells) | Inducer (gastric cancer cells, non-small cell lung cancer cells, salivary adenoid cystic carcinoma cells) | ND |
| Suppressor (lung cancer cells) | ND | |||
| Elk3 | - | Inducer (liver fibrosis) | Inducer (breast cancer cells) | ND |
| Brachyury | Required for mesoderm formation as well as cell movement during gastrulation | Inducer (kidney fibrosis) | Inducer (pancreatic cancer cell line, lung carcinoma cells, oral squamous carcinoma cells, kidney cells) | ND |
| FOSL1 | - | - | Inducer (prostate cancer cells, non-small cell lung cancer cells, mammary epithelial cells) | TGFB1, ZEB1, ZEB2 (mammary epithelial cells) |
| FOSL2 | - | - | Inducer (prostate cancer cells, non-small cell lung cancer cells) | ND |
| JunB | - | Inducer (kidney fibrosis) | Inducer (mammary epithelial cells, uveal melanoma cells) | ND |
| OVOL1 | - | - | Suppressor (prostate cancer cells, triple negative breast cancer cell) | ND |
| OVOL2 | Inducer of MET (fibroblasts) | Suppressor (prostate cancer cells, triple negative breast cancer cell) | ZEB1 (prostate cancer cells) | |
| ALX1 | - | - | Inducer (ovarian cancer cells, breast epithelial cells) | ND |
| ZBTB38 | - | - | Inducer (bladder cancer cells) | ND |
| TFAP2A | - | Positive regulator (human ventricular fibroblasts) | Suppressor (breast epithelial cells) | ZEB2 (breast epithelial cells) |
| BACH1 | - | Inducer (lung fibrosis) | Inducer (esophageal squamous cell carcinoma, pancreatic cancer metastasis) | CDH2, SNAI2, Vimentin, VEGFC (esophageal squamous cell carcinoma) |