. 2021 Dec 10;8:778283. doi: 10.3389/fmed.2021.778283

Table 2.

Comparisons of the parameters of the ganglion cell degeneration and microvasculopathy in the normal (no DM), DM (no DR), NPDR, and PDR groups.

	Control	DM	NPDR	PDR	*F/χ2*	P-value
	(N = 28)	(N = 21)	(N = 33)	(N = 22)	(all)	(all)
rmtRNFL [mean ±SD or median (interquartile range)]	0.10 (0.10, 0.11)	0.11 ± 0.01	0.11 (0.11, 0.12)	0.13 ± 0.02	35.10^b	<0.001^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.007*	<0.001 ^*	0.249	<0.001 ^*	0.039 ^*
rmtGCL [mean ±SD or median (interquartile range)]	0.26 ± 0.02	0.27 ± 0.01	0.27 ± 0.02	0.25 ± 0.02	5.38^a	0.002^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	1.000	0.040 ^*	1.000	0.002 ^*	0.009 ^*
rmtGCC [mean ±SD or median (interquartile range)]	0.37 ± 0.02	0.38 ± 0.01	0.38 ± 0.03	0.38 ± 0.03	2.08^a	0.108
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.127	0.375	1.000	1.000	1.000
SCP vessel density, % (mean ± SD)	29.12 ± 3.98	27.88 ± 4.18	26.25 ± 4.94	26.25 ± 3.72	2.45^a	0.067
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.094	0.161	1.000	1.000	1.000
DCP vessel density, % [mean ± SD or median (interquartile range)]	30.77 ± 2.94	30.13 ± 2.81	28.58 ± 6.22	25.28 ± 2.76	24.846^b	<0.001^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.144	<0.001*	0.457	<0.001 ^*	0.050 ^*
FAZ area in superficial capillary plexus, mm² [mean ± SD or median (interquartile range)]	0.36 ± 0.14	0.34 ± 0.10	0.47 ± 0.17	0.57 ± 0.25	17.54^b	0.001^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.095	0.002 ^*	0.197	0.006 ^*	0.846
FAZ area in deep capillary plexus, mm² (mean ± SD or median (interquartile range)]	0.52 ± 0.21	0.59 ± 0.16	0.69 ± 0.21	0.79 ± 0.31	12.83^b	0.005^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.040 ^*	0.007 ^*	0.873	0.227	1.000
FAZ perimeter in superficial capillary plexus, mm [mean ± SD or median (interquartile range)]	2.29 ± 0.49	2.32 ± 0.33	2.86 ± 0.54	3.15 (2.67, 4.07)	23.82^b	<0.001^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.005 ^*	<0.001 ^*	0.057	0.004 ^*	1.000
FAZ perimeter in deep capillary plexus, mm [mean ± SD or median (interquartile range)]	2.67 ± 0.61	3.19 (2.80, 3.31)	3.31 (2.81, 3.94)	4.14 ± 1.34	22.92^b	<0.001^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		0.557	0.009 ^*	<0.001 ^*	1.000	0.023 ^*	0.392
FAZ-CI in superficial capillary plexus [mean ± SD or median (interquartile range)]	0.82 ± 0.10	0.79 ± 0.08	0.71 ± 0.13	0.65 ± 0.21	14.50^b	0.002^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		1.000	0.011 ^*	0.008 ^*	0.395	0.241	1.000
FAZ-CI in deep capillary plexus [mean ± SD or median (interquartile range)]	0.88 ± 0.04	0.78 ± 0.08	0.75 ± 0.10	0.63 ± 0.19	36.54^b	<0.001^*
		p _DMvs.Normal	p_{NPDRvs.Normal}	p_PDRvs.Normal	p_NPDRvs.DM	p_PDRvs.DM	p_PDRvs.NPDR
		0.004 ^*	<0.001 ^*	<0.001 ^*	1.000	0.090	0.336

Statistically significant: P ≤ 0.05. According to the type of data and the data distribution, ^aone-way ANOVA analysis, Post-hoc Bonferroni's statistic, ^bKruskal–Wallis test, and ^cChi-square test were applied.

SD, standard deviation; rmtRNFL, relative mean thickness of retinal nerve fiber layer; rmtGCL, relative mean thickness of ganglion cell layer; rmtGCC, relative mean thickness of ganglion cell complex; SCP, superficial capillary plexus; DCP, deep capillary plexus; FAZ, foveal avascular zone; FAZ-CI, circularity index of the foveal avascular zone; DM, diabetes mellitus; NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.