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. 2021 Dec 10;12:755871. doi: 10.3389/fphar.2021.755871

FIGURE 1.

FIGURE 1

Probiotic lyophilized formulations can interfere with weight loss in mice with 5-FU-induced mucositis. Variation in body weight of mice (in percentage) over the last 5 experimental days (A) of animals that were gavaged with: PBS pH 7.4 (Naive group and 5-FU inflamed control group); 12% skimmed milk supplemented with 30% WPI and Fructooligosaccharide (Matrix); a formulation containing L. casei BL23, a formulation containing the mix of probiotics (Symbiotic). (B) Body weight variation (in percentage) observed after the last experimental day (14th day) considering the 10th experimental day as initial weight (100%). Animals gavaged with PBS was used as experimental controls. The one-way or two-way ANOVA test, followed by Sidak or Tukey post-test was used for the multiple comparisons between groups (n = 6–9). Asterisks represent statistically significant differences as follows: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.