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. 2021 Dec 10;12:755871. doi: 10.3389/fphar.2021.755871

FIGURE 2.

FIGURE 2

Probiotic lyophilized formulations can reduce inflammation in the duodenal, jejunum, and ileum section of 5-FU-induced mucositis mice. (A, B, C) Photomicrographs of the duodenal, jejunum, and ileum of BALB/c mice, stained in HE, induced or not to mucositis by 5-FU and those that received the probiotic lyophilized formulations. The animals were gavage with: PBS pH 7.4 (Naive group and 5-FU inflamed control group); 12% skimmed milk supplemented with 30% WPI and Fructooligosaccharide (Matrix); a formulation containing L. casei BL23, a formulation containing the mix of probiotics (Symbiotic). The photos show the ×20 magnification. Scale bar = 100 µm (D, E, F) Histopathological score of the duodenal, jejunum, and ileum section. Results were expressed as means ± standard deviation (n = 6–9). One-way ANOVA and Tukey post-hoc tests were used for multiple comparison. Asterisks represent statistically significant differences as follows: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.