FIGURE 6.

Probiotic lyophilized formulations can modulate cytokine production in the ileum section of mice with 5-FU-induced mucositis. Cytokine levels (A IL-1β, IL-6, IL- 10, IL-17, TNF-α, and INF-γ ratio were determined in mouse ileum tissue supernatant by ELISA. The animals were gavaged with: PBS pH 7.4 (Naive group and 5-FU inflamed control group); 12% skimmed milk supplemented with 30% WPI and Fructooligosaccharide (Matrix); a formulation containing L. casei BL23, a formulation containing the mix of probiotics (Symbiotic). Means and standard deviations are calculated from 3 animals per group, from 3 independent repetitions, and each quantification was performed in triplicate (technical triplicates). Asterisks represent statistically significant differences between strains and were indicated as follows:*p < 0.05; **p < 0.01; ***p < 0.001 and ****p < 0.0001.