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. 2021 Nov 20;298(1):101440. doi: 10.1016/j.jbc.2021.101440

Figure 6.

Figure 6

Gβγ drives ARHGEF17-dependent actin cytoskeleton reorganization. The hypothetical effect of Gβγ on ARHGEF17-dependent actin cytoskeleton reorganization is depicted in (C, E, and G). Control conditions are depicted in (A). Representative PAE cells stained with red fluorescent phalloidin are shown in (B, D, F, and H). Cells were transfected with EGFP, EGFP-GEF17, EGFP-GEF17-N-DHPH, EGFP-GEF17-DHPH-C together or not with FLAG-Gβγ as indicated. Graphs represent the mean ± SEM from three independent experiments (at least 30 cells per condition). ∗∗∗∗p < 0.0001, ∗∗∗p < 0.001; t test; ns. The scale represents 20 μm; zoom represents 10 μm. EGFP, enhanced GFP; ns, nonsignificant; PAE, porcine aortic endothelial.