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. 2001 Jun;21(11):3789–3806. doi: 10.1128/MCB.21.11.3789-3806.2001

TABLE 2.

C/EBPα-regulated genes identified by nucleotide arraya

Type of gene and sequence accession no. Xb Yc Y/20/Xd Xe Ye
Down-regulated
 No cluster in current Unigene (T50334_f) 191 74 0.387 P P
 Platelet-endothelial tetraspan antigen 3f(R74349) 162 58 0.358 P P
 Heterogeneous nuclear ribonucleoproteinf (X16135) 158 56 0.354 P P
 Tetracycline transporter-like proteinf (H28711) 159 56 0.352 P P
 Myb proto-oncogene (M13665) 325 108 0.332 P P
 Natural killer cell protein 4 precursor (M59807) 180 58 0.322 P P
 Cathepsin G precursor (J04990) 867 268 0.309 P P
 Nonmetastatic cell 1 (NME1) (T86473) 133 41 0.308 P P
 HLA-DRB1, major histocompatibility complex class II (T62633) 332 86 0.259 P P
 MacMarcks (D44497) 370 93 0.251 P P
 c-Myc (X00364) 82 10 0.243 P P
 Calmodulin (U10117) 105 25 0.238 P A
 ARHG, Ras homolog family, rho Gg (X61587) 140 33 0.235 P P
 E1F4A (eukaryotic translation initiation factor 4A)h (T69446) 111 26 0.234 P P
 PTMA (α-prothymosin)h (R98842) 142 33 0.232 P A
 PRTN3 (proteinase 3) (M96839) 167 36 0.215 P P
 No cluster in current Unigene (H43328_i) 95 7 0.210 P A
 FLN1 (filamin 1; actin-binding protein) (R78934) 115 12 0.173 P A
 CALR (autoantigen calreticulin) (M84739) 568 89 0.156 P P
 E1F5A (eukaryotic translation initiation factor 5A)h (R72300) 182 −62 0.109 P P
Up-regulated
 Arginase (ARG1) (M14502) 3 351 17.55 A P
 Antithrombin III precursor (D29832) 37 622 16.81 P P
 Haptoglobin (HP) (T67511) 12 300 15.00 A P
 Annexin 1 (ANX1; lipocortin 1) (X05908) 23 345 15.00 P P
 HMOX1 (heme oxygenase 1) (X06985) 11 278 13.9 A P
 HLA-G, major histocompatibility complex class proteinh (M32800) 23 261 11.35 A P
 DDH1 (dihydrodiol dehydrogenase) (T64167) −2 204 10.20 A P
 dUTP pyrophosphatase (T50797) 11 162 8.10 P P
 No cluster in current Unigene (T55731) 95 750 7.89 P P
 No cluster in current Unigene (T71025) 151 1,081 7.16 P P
 NMB (neuromedin B) (X76534) 9 143 7.15 A P
 Small nuclear ribonucleoprotein polypeptides B and B1 (R8411) 74 517 6.99 P P
 Protease inhibitor 12 (H09572) −3 138 6.90 A P
 Prolactin (H51034) 3 117 5.85 A P
 Calgranulin A (T99219) 109 632 5.80 P P
 Ubiquitin A-52i 155 888 5.73 P P
 Oligo(A) synthetase (2′–5′)hi (X02875) 12 113 5.65 A P
 Ribosomal protein S4 (R05923) 14 111 5.55 P P
 No cluster in current Unigene (H29761) 5 111 5.55 A P
 Protein tyrosine phosphatase receptor type c (Y00062) 22 122 5.55 P P
 PSMB5, proteasome subunit (H87473) 16 109 5.45 P P
 Bcl-2 related (Bfl-1) (U27467) 15 104 5.20 P P
 Glycogenin (U31525) 42 218 5.19 P P
 Vimentin (T51852) 98 504 5.14 P P
 No cluster in current Unigene (R59583) 27 131 4.85 P P
 Autotaxin (L35594) −7 96 4.80 A P
 Expressed sequence tag (T94579) 19 93 4.65 A P
 No cluster in current Unigene (M26311) 52 234 4.50 P P
 H2AZ histone (M37583) 18 90 4.50 P P
 Pre-P-cell enhancing factor (U02020) 15 89 4.45 A P
 RNA polymerase II subunit (U37690) 22 94 4.27 P P
 Ferritin heavy chain (T63508) 33 139 4.21 P P
 Heat shock 10-kDa protein 1 (R08183) 132 536 4.06 P P
 Glyoxalase 1 (D13315) 73 289 3.96 P P
 Expressed sequence tag (T59954) 98 383 3.91 P P
 Cystatin A (X05978) 114 403 3.54 P P
 No cluster in current Unigene (T61661) 149 509 3.42 P P
 KIAA0108f (D14696) 78 258 3.31 P P
 Expressed sequence tag (H06970) 82 268 3.27 P P
 PABPL [poly(A)-binding protein-like 1] (T64148) 32 102 3.19 P P
 Heat shock 27-kDa protein 1 (T48904) 760 2,396 3.15 P P
 Myosin regulatory light chain (T78489) 40 126 3.15 P P
 Nucleobindin precursor (R52271) 48 150 3.13 P P
 Ribosomal protein S11 (H89983) 41 128 3.13 P P
 SSB (Sjögren syndrome antigen B)f (H29485) 51 148 2.90 P P
 Ubiquitin carrier protein (E2-EPF) (M91670) 248 704 2.84 P P
 Surface antigen (M60922) −18 56 2.80 A P
 LRPAP1 (low-density lipoprotein-related protein) (M63959) 104 274 2.63 P P
 PSMA5 (proteasome component C5) (D00761) 60 157 2.62 P P
 Eletron-transfer flavoprotein (J04058) 51 134 2.63 P P
 Adenosine receptor A1 (L22214) 56 145 2.59 M P
 No cluster in current Unigene (H05222) 57 147 2.58 A A
 Putative protein kinase C inhibitor (H46728) 67 171 2.55 P P
 ATP6B2, ATPase, H+ transporter (L35249) 74 188 2.54 P P
a

DNA fragments identified by nucleotide array analysis, U937/MT-C/EBPα zinc-stimulated cells compared with unstimulated cells. Results are listed by decreasing Y/20/X values. 

b

Fluorescence intensity with RNA from cells before zinc stimulation. 

c

Fluorescence intensity with RNA from cells 8 or 24 h following stimulation. 

d

All intensities below 20 are adjusted to 20, which is within background. For down-regulated genes, data were sorted for expression differences of <0.4-fold using data more than 70-fold above the lower value. For up-regulated genes, data were sorted for expression differences of >2.5-fold using data more than 70-fold above the lower value. 

e

P, present; A, absent; M, undetermined. 

f

Gene potentially regulated by c-Myc, as indicated by Transfac transcription factor binding site search. 

g

Gene potentially regulated by E2F, as indicated by Transfac transcription factor binding site search. 

h

Known c-Myc target gene. 

i

Gene identified also by RDA screen.