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editorial
. 2021 Nov 2;13(1):348–349. doi: 10.1016/j.jcmgh.2021.10.006

Table 1.

Illustration of the Impact of Different NK Depletion Methods on cNK, lrNK, and NKT Cells

cNK lrNK NKT Disease in MCD model
Nfil3-/- Depleted Retained Retained Ameliorated7
NKp46-depleted Depleted Depleted Retained Exacerbated6
PK136 Abs Depleted Depleted Depleted Ameliorated7
Suggested role Pathogenic Protective Pathogenic

NOTE. The reported outcome regarding the disease severity in MCD mouse model is specified for each method. Based on these findings, the pathogenic or protective role for each cell type is suggested.

Abs, antibodies; cNK, conventional NK; lrNK, liver-resident NK; MCD, methionine- and choline-deficient diet; NK, natural killer cells; NKT, natural killer T cells.