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. 2021 Dec 10;8:808940. doi: 10.3389/fmed.2021.808940

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Copyright © 2021 Yang, Chen, Zhai, Dai, Gu, Zhou and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DED in mouse model. (A) Administration of 0.2% BAC in both eyes for 14 days in DED group. Examinations were taken at day 0, day 7, day 14, and day 21. (B) Topical 5 μl of 0.2% BAC and PBS were applied twice a day. (C) Representative images of fluorescence sodium staining on day 14 in a DED cornea compared with images of the control cornea. (D) Representative images of tear production on day 14 after DED animal modeling. (E) The fluorescein scores at day 7, day 14, and day 21 were significantly increasing over time in the cornea of the DED mice (all p < 0.001). (F) Significant reduction of wetted length was observed in the DED group compared with the controls (p < 0.01). DED, dry eye disease; BAC, benzalkonium chloride; PBS, phosphate buffered saline.