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. 2021 Dec 10;8:808940. doi: 10.3389/fmed.2021.808940

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Copyright © 2021 Yang, Chen, Zhai, Dai, Gu, Zhou and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioinformatic functional analysis of differentially expressed lncRNAs. (A) Heatmap of expression levels of tissue-specific lncRNAs. (B) Volcano plot of the different lncRNAs expression in each group. (C) Venn diagram showing co-location or co-expression of lncRNA-target genes (mRNAs). (D) The number of differentially expressed lncRNAs in BP, CC, and MF. (E) Expression levels of the top three upregulated lncRNAs in both groups via RT-qPCR. (F) Expression levels of the top three downregulated lncRNAs in both groups via RT-qPCR. CC, cellular component; MF, molecular function; BP, biological process. *p < 0.05, **p < 0.01. DED, dry eye disease.