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. 2021 Dec 10;9:778011. doi: 10.3389/fcell.2021.778011

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Copyright © 2021 Zhang, Feng, Li, Wu, Wang, Li and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Degradation pathway of PINK1 in normal mitochondria. In normal mitochondria, PINK1 is imported into mitochondria utilizing the translocase complex of the outer membrane (TOM) and the translocase (TIM) of the inner membrane. In the inner mitochondrial membrane (IMM), ① is followed by proteolytic cleavage of full-length PINK1 by mitochondrial processing peptidase (MPP) processing and the intermembrane serine protease progerin-associated rhomboid protein (PARL), which cleaves full-length PINK1 into a 52 kDa fragment that is subsequently degraded by proteasomes via the conventional N-terminal pathway. ② It is also thought to be degraded at the mitochondrial–endoplasmic reticulum (ER) interface.