TABLE 1.

Summary of drugs aimed at improving mitochondrial dysfunction in DKD.

Agent	Mechanism	Model	Influence factor	Effect on DKD and repair	Effect on mitophagy	Pub. year	References
d-gluconic	inhibitor of MIOX	diabetic mice	PINK1, MIOX, ROS	Attenuated DKD	Promote	2015	Zhan et al. (2015)
CoQ10	Mitochondria-targeted antioxidant	db/db type 2 diabetic mice	MtROS, Nrf2/ARE	Attenuated DKD	Promote	2019	Sun et al. (2019)
MitoQ	Mitochondria-targeted antioxidant	db/db mice	Nrf2/Keap1 and PINK/Parkin	Attenuated DKD	Promote	2017	Xiao et al. (2017)
HDD		db/db mice	PINK1/Parkin	Reduces urinary albumin excretion and improves kidney injury	Restrain	2020	Liu et al. (2020b)
AS-IV		db/db mice		Attenuated DKD	Restrain	2017	Liu et al. (2017)
metformin			PP2A, NF-κB, Parkin	Attenuated DKD	Promote	2020	Zhao and Sun (2020)