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. 2021 Dec 10;12:748387. doi: 10.3389/fimmu.2021.748387

Figure 2.

Figure 2

Liver Egg burdens after repeated cycles of S. mansoni infection and PZQ treatments. Outcome measure = Egg accumulation rate in liver (A) Liver Egg burdens are displayed for mice after first (1°) and second (2°) infection cycle with 35 S. mansoni cercariae and analysed at week 15 i.e. P1. (B) Liver egg burden changes in animals undergoing their first (0 to 1°) or second (1° to 2°) cycle of infection intercalated by PZQ treatment rounds and analysed at week 15 i.e. P1 (C) Liver Egg burdens are displayed for mice after first (1°), second (2°) and third (3°) infection cycle with 35 S. mansoni cercariae after 25 weeks i.e. P2. PZQ treatment was administered daily at 400mg/kg by oral gavage twice at the end of each infection cycle of 6-8 weeks. The interrupted line represents the linear prediction of tissue egg burden after repeated infection hypothetically similar in susceptibility as infection 1°. (D) Liver egg burden changes in animals undergoing their first (0 to 1°), second (1° to 2°) or third (2° to 3°) cycle of infection intercalated by PZQ treatment rounds at week 25 i.e. P2. Data shown are means ± SEM from one of 2 experiments, with 4-7 mice per group in each experiment. NS = p > 0.05; * = p < 0.05; ** = p < 0.01 as determined by Kruskal-Wallis test with correction for multiple comparisons by Dunn’s test (A, C, D) or by two-tailed Mann Whitney U test (B).