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. 2021 Dec 10;12:748387. doi: 10.3389/fimmu.2021.748387

Figure 4.

Figure 4

Liver fibropathology after repeated cycles of S. mansoni infection and PZQ treatments. Outcome measure = Advancement of liver fibroproliferative processes in animals (A) Upper panel shows a gross view of larger liver lobe of mice after differential scheme of infection/PZQ treatments after 15 weeks (P1) and lower panel illustrated the liver lobes after 25 weeks (P2). Note that resolution for both time points differs. For P1, (B) upper panel shows Fraction areas of fibrosis (blue deposition of collagen) over the entire lobe scanned are computed as a proxy for the stage of advancement of liver fibrosis and lower panel shows serum AST/ALT ratios computed for mice groups subjected to different schemes of infection/PZQ treatments. For P2, (C) upper panel shows Fraction areas of fibrosis (blue deposition of collagen) over the entire lobe scanned are computed as a proxy for the stage of advancement of liver fibrosis and lower panel shows serum AST/ALT ratios computed for mice groups subjected to different schemes of infection/PZQ treatments. Data shown are means ± SEM from one of 2 experiments, with 4-7 mice per group each. * = p < 0.05 as determined Kruskal-Wallis test with correction for multiple comparisons by Dunn’s test. Only significant comparisons between groups are displayed.