Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 10;12:764509. doi: 10.3389/fgene.2021.764509

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Qiao, Chen, Tan, Sun, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Functional assessment of variants p.P244S, p.C264F, and p.L504P. The expression of soluble protein was significantly reduced (A) and remained unchanged after MG132 treatment (C). No dramatic change in auto-phosphorylation was detected (A). The expression of insoluble protein was also significantly reduced with increased phosphorylation level (B). In addition, protein degradation was reversed in p.P244S and p.C264F, while p.L504P was unresponsive to proteasomal inhibition (D). Sol, soluble; Ins, insoluble; PY, phosphotyrosine; WT, wild type; MG, MG132.^a