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. 2021 Dec 10;12:764509. doi: 10.3389/fgene.2021.764509

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Copyright © 2021 Qiao, Chen, Tan, Sun, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional assessment of cytodomain variants p.L888P and p.R1003H. The protein expression and auto-phosphorylation levels of p.L888P are comparable to that of wild type (A, B). However, p.R1003H is significantly phosphorylated in soluble portion (A) and enriched in insoluble fraction (B), which does not respond to MG132 treatment (C, D). Sol, soluble; Ins, insoluble; PY, phosphotyrosine; WT, wild type; MG, MG132.