Fig. 3.

ARCoV vaccination protects from SARS-CoV-2 infection and its associated lung damages in cynomolgus macaques. a Immunostaining of lung tissues. SARS-CoV S proteins were indicated in green, and the area in the white box is magnified in right. Scale bar, 200 μm. b ISH assays for SARS-CoV-2 RNA. Positive signals are shown in brown (red arrowhead). Scale bar, 200 μm. c Hematoxylin and eosin (H&E) staining of lung tissues. Scale bar, 200 μm. d Heat map showing scores in each lung histopathological criterion from all animals. Severity in lung tissue lesions ranges from 0 to 9: 0 for normal, 1–3 for minimal, 4–6 for mild, 7–9 for moderate. e Graph for showing the average scores for all the lung histopathology criterions from the combined lobes per animal