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. 2021 Dec 10;12:789519. doi: 10.3389/fphys.2021.789519

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Copyright © 2021 LeDuc, Skowronski and Rosenbaum.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Leptin functions in mice during gestation, lactation, and adulthood. (A) In the gestational period, leptin mediates neurogenesis and proliferation of other brain cells (not limited to gestation). (B) During the immediate postnatal (lactational) period, mice undergo a leptin surge that is critical for the outgrowth of projections from feeding circuit essential neurons. (C) In adult mice, leptin is produced in rough proportion to stable fat mass, informs the CNS about energy stores, and protects against fat loss (Figure created with BioRender.com).