Figure 5.

Comparison between the estimated coefficients of metaboWAS on T2D adjusted for BMI or for surrogate ‘obesity’. On the x-axis the metaboWAS for diabetes adjusting for BMI and on the y-axis the metaboWAS for diabetes adjusted for surrogate obesity. The dataset composed of 1,697 individuals, 79 of which are diabetics. Estimated coefficients for each metabolite (points) are colored based on their significance in the two models: purple: significant in both; red: significant when adjusted for BMI only; blue: significant when adjusted for surrogate obesity only; black never significant. Lower right corner: a contingency table with the number of significant and non-significant metabolites identified using the two models.