Table 1.
Further Reading: Meta-analysis studies conducted regarding MTHFR polymorphisms in various ethnic groups and associated metabolic diseases.
| Study Title | Associated Disease | Reference |
|---|---|---|
| MTHFR 677T variant contributes to diabetic nephropathy risk in Caucasian individuals with type 2 diabetes: a meta-analysis | T2DM | [59] |
| Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility | T2DM | [74] |
| The effect of MTHFR C677T polymorphism on type 2 diabetes mellitus with vascular complications in Chinese Han population: a meta-analysis | T2DM and vascular complications | [75] |
| Methylenetrahydrofolate Reductase Gene C677T Polymorphism and Diabetic Retinopathy: a Meta-Analysis | DR | [76] |
| Methylenetetrahydrofolate reductase A1298C polymorphism and diabetes risk: evidence from a meta-analysis | T2DM | [77] |
| Association between MTHFR C677T polymorphism and diabetic nephropathy in the Chinese population: An updated meta-analysis and review | DN | [78] |
| Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis | T2DM and DN | [79] |
| Increasing prevalence of gestational diabetes mellitus when carrying the T variant allele of the MTHFR gene C677T polymorphism: a systematic review and meta-analysis | Gestational diabetes | [80] |
| Relationship between methylenetetrahydrofolate reductase (MTHFR) A1298C gene polymorphism and type 2 diabetic nephropathy risk: a meta-analysis | T2DM and DN | [81] |
| A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy | DR | [82] |
| Genetics of diabetic neuropathy: Systematic review, meta-analysis and trial sequential analysis | DN | [83] |
| Methylenetetrahydrofolate reductase C677T polymorphism and type 2 diabetes mellitus in Chinese population: a meta-analysis of 29 case-control studies | T2DM | [84] |
| Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization | Obesity risk | [85] |
| Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach | T2DM | [86] |
| Effects of Common Polymorphisms in the MTHFR and ACE Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis | DN | [87] |
| ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis | T2DM | [88] |
| Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus | T2DM and DN | [89] |
| Association between MTHFR C677T polymorphism and diabetic nephropathy or diabetes mellitus risk: need for clarification of data in a recent meta-analysis | T2DM and DN | [90] |
| Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population | DR | [91] |
| The relationship between methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy: A meta-analysis in multi-ethnic groups | DR | [92] |
| MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis | DN | [93] |
| Genetic susceptibility to type 2 diabetes: a global meta-analysis studying the genetic differences in Tunisian populations | T2DM | [94] |
| Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses | T2DM | [95] |
| An updated meta-analysis of methylenetetrahydrofolate reductase gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathy | DR and DN | [96] |
| Methylenetetrahydrofolate reductase genetic polymorphism and the risk of diabetic nephropathy in type 2 diabetic patients | T2DM and DN | [97] |
| Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians | T2DM | [98] |
| Is C677T polymorphism in methylenetetrahydrofolate reductase gene a risk factor for diabetic nephropathy or diabetes mellitus in a Chinese population? | T2DM and DN | [99] |
| Interactions among Candidate Genes Selected by Meta-Analyses Resulting in Higher Risk of Ischemic Stroke in a Chinese Population | Ischemic stroke | [100] |
| No Evidence of a Causal Relationship between Plasma Homocysteine and Type 2 Diabetes: A Mendelian Randomization Study | T2DM | [101] |
T2DM, type 2 diabetes mellitus; DN, diabetic nephropathy; DR, diabetic retinopathy.