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Schematic representation of donor replicon RNA templates. The genetic structure is shown for EV71/rep, E7/rep, PV1/rep, PV3/rep, and EV70/rep. Numbers below refer to the nucleotide number within VP1 at which the virus sequence restarts, relative to its position in the full-length genome. For EV70/rep, we also denoted the last nucleotide of the VP4 fragment present upstream of the luciferase gene.
