Table 1.
Plasma fatty acid composition in WT and Thy1-αSyn mice.
| Fatty Acids (pmol/mL) |
WT | Thy1-αSyn (Tg) | Mean Testing p-Values | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CTRL | CTRL | Low n-3 PUFA | DHA | ANOVA | WT vs. Tg |
CTRL vs. Low |
CTRL vs. DHA |
Low vs. DHA |
||
| ω-3 PUFA | ||||||||||
| DHA | 22:6n3 | 12.3 ± 0.6 | 16.7 ± 2.1 | 3.5 ± 0.8 | 162.2 ± 9.0 | **** † | >0.9999 | ** | ** | **** |
| n-3 DPA | 22:5n3 | 2.1 ± 0.1 | 4.2 ± 0.5 | 15.3 ± 2.4 | 21.7 ± 1.5 | **** † | 0.0877 | 0.1952 | ** | >0.9999 |
| EPA | 20:5n3 | 0.34 ± 0.02 | 0.49 ± 0.05 | 0.10 ± 0.02 | 4.71 ± 0.29 | **** † | 0.6743 | ** | * | **** |
| SDA | 18:4n3 | 0.030 ± 0.006 | 0.121 ± 0.025 | 0.025 ± 0.009 | 0.184 ± 0.016 | **** ‡ | **** | ** | * | **** |
| ω-6 PUFA | ||||||||||
| AA | 20:4n6 | 13.8 ± 0.8 | 15.5 ± 1.6 | 18.6 ± 1.2 | 8.8 ± 0.4 | **** † | >0.9999 | 0.6492 | *** | **** |
| LA | 18:2n6 | 12.7 ± 0.9 | 22.0 ± 2.4 | 23.9 ± 1.6 | 13.6 ± 0.6 | **** ‡ | **** | 0.8281 | *** | **** |
Abbreviations: AA, arachidonic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; LA, linolenic acid; PUFA, polyunsaturated fatty acids; SDA, stearidonic acid; WT, wild-type. Values are represented as mean ± SEM (C57, n = 29; Tg-CTRL, n = 13; Tg-Low, n = 9; Tg-DHA, n = 18). Differences between genotype and between diet in transgenic mice were compared by † Kruskal–Wallis test with Dunn’s multiple comparisons or ‡ one-way ANOVA with Tukey post-hoc. Significant differences in means: * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001.